With respect to BD increased HPA activity has been associated with mixed manic states depression and less consistently with classical manic episodes 318. Prior to initiating Bupropion hydrochloride screen patients for a history of bipolar disorder and the presence of risk factors for bipolar disorder eg family.
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The risk appears to be increased in patients with bipolar disorder or who have risk factors for bipolar disorder.
. Antidepressant treatment can precipitate a manic mixed or hypomanic manic episode. In humans magnetic resonance imaging MRI. Chronic stress or glucocorticoid administration has been demonstrated to produce atrophy and death of vulnerable hippocampal neurons in rodents and primates.
Prior to initiating Contrave screen patients for a history of bipolar disorder and the presence of risk factors for bipolar disorder eg family history of bipolar disorder suicide. The risk appears to be increased in patients with bipolar disorder or who have risk factors for bipolar disorder. In animals quetiapine has been associated with the development of cataracts and cataracts have been reported in patients using quetiapine for prolonged periods.
Although it is not clear if quetiapine was responsible for the cataracts seen in humans eye examinations by slit-lamp to identify cataracts before they impair vision are recommended at the beginning of treatment. Antidepressant treatment can precipitate a manic mixed or hypomanic episode.
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